Each serving (3 capsules) of actimine contains:

• Methylsulfonyl Methane 1000 mg (Daily Value: *)
• Vitamin C 500 mg (Daily Value: 833%)
• Echinacea Purpurea 100 mg (Daily Value: *)
• Vitamin E 30 IU (Daily Value: 100%)
• Quercetin 50 mg (Daily Value: *)
• Grape Seed Ext. 25 mg (Daily Value: *)
• Stinging Nettle 25 mg (Daily Value: *)
• Coleus Forskolin 15 mg (Daily Value: *)

Other Ingredients: Gelatin, Rice Powder, Magnesium Stearate.
*Daily Value Not Established

Daily Dosage: Take one capsule one hour before each meal. If an upset stomach occurs take each capsule with a meal.

Historal Research

Methylsulfonyl Methane - Has been shown to have anti-allergic properties better than or equal to antihistamines.

Vitamin C - It was first discovered to be useful for allergies in the 1940's. (1) New studies reveal that Vitamin C is effective because it can metabolize and detoxify histamines. (2)

Echinacea Purpurea - Promotes the health of your immune system.

Vitamin E - Supports the immune system. It is best known for its antioxidant uses and can help with many different symptoms.

Quercetin - Studies show this may be effective because it can inhibit the release of histamines from mast cells. (3) In conjunction with Vitamin C, Quercetin may help reduce the severity of hay fever symptoms. (4)

Grape Seed Ext. - Contains an active ingredient called "proanthocyanidins or PCO's" which benefit the body by neutralizing "free radicals."

Stinging Nettle - A randomized, double-blind study that included 92 individuals showed that stinging nettle was more effective than placebo in relieving symptoms of allergic rhinitis. (5)

Coleus Forskolin - May help with blood pressure and muscle relaxation. (6,7 )

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References:

1. Ruskin SL. High dose vitamin C in allergy. Am J Dig Dis. 1945;12:281.

2. Clemetson CA. Histamine and ascorbic acid in human blood. J Nutr. Apr1980;110(4):662-8.

3. Bronner C, Landry Y. Kinetics of the inhibitory effect of flavonoids on histamine secretion from mast cells. Agents Actions. 1985;16(3-4):147-151.

4. Middleton E, Drzewicki G. Effect of ascorbic acid and flavonoids on human basophil release. J Allerg Clin Immunol. Jan1992:278.

5. Mittman P. Randomized, Double-blind Study of Freeze-dried Urtica dioica in the Treatment of Allergic Rhinitis. Planta Med. Feb1990;56(1):44-47.

6. Bhat SV, et al. The Antihypertensive and Positive Inotropic Diterpene Forskolin: Effects of Structural Modifications on Its Activity. J Med Chem. 1983;26:486-92.

7. Baumann G, et al. Cardiovascular Effects of Forskolin (HL 362) in Patients with Idiopathic Congestive Cardiomyopathy -- A Comparative Study with Dobutamine and Sodium Nitroprusside. Cardiovasc Pharmacol. 1990;16(1):93-100.